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PDGFR alpha (G680R), Active

Recombinant human PDGFRα (G680R) (550-end) was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.
Catalog No. P12-12DG


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Catalog No. Pack Size Price (USD)
P12-12DG-05 05 ug $226
P12-12DG-10 10 ug $325
P12-12DG-BULK BULK Contact Us  


Overview:

PDGFRα (platelet-derived growth factor receptor a) is a member of the PDGFR family of membrane receptors with intrinsic tyrosine kinase activity. Aberrant expression of PDGFRα has been linked to developmental abnormalities in vertebrate models and has been implicated in multiple disease states in humans. There is widespread expression of PDGFRα in renal cell types involved in fibrotic and sclerosing processes (1). PDGF and its receptor PDGFRα are inducers of fibrosis in the repair phase of inflammatory bowel disease and they may also be involved in the active inflammatory phase (2). PDGFRa(T674I) is one of the mutant forms of PDGFRa.


Gene Aliases:

CD140A, PDGFR2, MGC74795, Rhe-PDGFRA


Genbank Number:



Specific Activity :

Sample Kinase Activity Plot. For specific information on a given lot, see the related technical datasheet.


Purity:

Sample Purity Data. For specific information on a given lot, see related technical data sheet.


Storage, Stability, and Shipping:

Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.


Molecular Weight:

Approx. MW 95 kDa.



Product Datasheets



There are no related publications available for this product.


RESEARCH AREAS

Apoptosis/Autophagy, Cancer, Cardiovascular Disease, Cell Cycle, Phosphatases, Receptor Tyrosine Kinases


RELATED PRODUCTS


  PDGFR alpha, Active, P12-11G

  PDGFR alpha, Active, P12-18G

  PDGFR beta, Active, P13-11G

  PDGFR alpha (T674I), Active, P12-12CG


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