STK3, also known as MST2, encodes a protein of 491-amino acid which contains an N-terminal catalytic domain characteristic of STKs (1). STK3 and STK4 share 94% amino acid identity in the catalytic domain and 78% identity overall. RAF1 has been shown to counteract apoptosis by suppressing the activation of mammalian sterile 20-like kinase (MST2). STK3 is a kinase that is activated by the proapoptotic agents straurosporine and FAS ligand (2). STK3 activation presumably allows cells to resist unfavorable environmental conditions.
KRS1; MST2; FLJ90748
1. Creasy, C L. et al: Cloning and characterization of a member of the MST subfamily of Ste20-like kinases. Gene 167: 303-306, 1995.
2. Lee, K K. et al: MST, a physiological caspase substrate, higly sensitizes apoptosis both upstream and downstream of caspase activation. J. Biol. Chem. 276: 19276-19285, 2001.
Sample Kinase Activity Plot. For specific information on a given lot, see related technical data sheet.
Sample Purity Data. For specific information on a given lot, see related technical data sheet.
Storage, Stability and Shipping:
Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Zhenkun L et al., Extracellular matrix stiffness determines DNA repair efficiency and cellular sensitivity to genotoxic agents Science Advances September 2020 10.1126/sciadv.abb2630
A Thorne Curtis et al., Small-molecule inhibition of Wnt signaling through activation of casein kinase 1α Nature Chemical Biology November 2010 10.1038/nchembio.453
AKT/PKB Pathway, Apoptosis/Autophagy, Cancer, Cardiovascular Disease, Inflammation, JNK/SAPK Pathway, Neurobiology, Ser/Thr Kinases