Overview:

DYRK4 or dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 4 plays an important role in cell proliferation, survival, and development (1). Northern blot analysis shows DYRK4 is highly expressed in the testis with a very restricted expression to stage VIII postmeiotic spermatids (2). Analysis of a DYRK4 deficient mouse line showed that DYRK4 is dispensable for male fertility, hence suggesting a functional redundancy of some DYRK isoforms during spermiogenesis. DYRK4 protein contains a DYRK homology box in its N-terminal half, followed by a central kinase domain with a YxY loop.

Gene Aliases:

None

Genbank Number:

NM_003845

References:

1. Zhang, D. et.al:DYRK gene structure and erythroid-restricted features of DYRK3 gene expression. Genomics 85: 117-130, 2005.

2. Becker, W. et.al:Sequence characteristics, subcellular localization, and substrate specificity of DYRK-related kinases, a novel family of dual specificity protein kinases. J. Biol. Chem. 273: 25893-25902, 1998.