PI3K inhibitor
Catalog No. P27-900B
| Catalog No. | Pack Size | Price (USD) | |
|---|---|---|---|
| P27-900B-01 | 1 mg | $90 | |
| P27-900B-05 | 5 mg | $270 | |
| P27-900B-BULK | BULK | Contact Us |
Overview:
Potent, selective, and irreversible inhibitor of phosphatidylinositol 3-kinase (PI 3-kinase) (IC50 = 2 - 4 nM). Also potently inhibits polo-like kinase 1 (PLK1) (IC50 = 5.8 nM). Cell-permeable.
References:
1. Arcaro and Wymann Biochem J. 1993 296:297
2. Powis et al Cancer Res. 1994 54:2419
3. Liu et al Chem .Biol. 2005 12:99
CAS Registry Number:
19545-26-7
Molecular Formula:
C23H24O8
Appearance:
White to off-white powder
Melting Point:
N/A
Molecular Weight:
428.4
Purity:
>98% (TLC); NMR (Conforms)
Solubilization:
May be dissolved in DMSO (20 mg/ml)
Aliases:
11-(acetyloxy)-1S,6bR,7,8,9aS,10,11R,11bR-octahydro-1-(methoxymethyl)-9a,11b-dimethyl-3H-furo[4,3,2-de]indeno[4,5-h]-2-benzopyran-3,6,9-trione
Storage and Stability:
Store desiccated as supplied at -20°C for up to 1 year. Make and use fresh solutions. Do not store stock solutions.
AKT/PKB Pathway, Angiogenesis, Apoptosis/Autophagy, Cancer, Cardiovascular Disease, Inflammation, Invasion/Metastasis, Lipid Kinases, Metabolic Disorder, Neurobiology, NfkB Pathway, WNT Signaling
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Yalcin Abdullah et al., Nuclear Targeting of 6-Phosphofructo-2-kinase (PFKFB3) Increases Proliferation via Cyclin-dependent Kinases* Journal of Biological Chemistry November 2012 10.1074/jbc.M109.016816 
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