Overview:

EPHA7 is a member of the ephrin receptor subfamily of protein-tyrosine kinases family that have been implicated in mediating developmental events, particularly in the nervous system. Receptors in the EPH subfamily typically have a single kinase domain and an extracellular region containing a Cys-rich domain and 2-fibronectin types III repeats. EPHA7 mediated signaling act as a physiologic trigger for apoptosis that can alter brain size and shape by regulating the number of neural progenitors (1). The high expression of EPHA7 protein plays an important role in the malignancy transformation, invasion progression and metastasis of primary hepatocellular carcinoma (2).

Gene Aliases:

CEK11, EHK3, HEK11, MDK1

Genbank Number:

BC026153

References:

1. Depaepe, V. et.al: Ephrin signalling controls brain size by regulating apoptosis of neural progenitors. Nature 435: 1244-1250, 2005.

2. Zhang SJ. et.al: Expression of EphA7 protein in primary hepatocellular carcinoma and its clinical significance. Zhonghua Wai Ke Za Zhi. 2010 Jan 1;48(1):53-6.