Full-length recombinant human AXIN2 was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.
Catalog No. A72-30G
| Catalog No. | Pack Size | Price (USD) | |
|---|---|---|---|
| A72-30G-20 | 20 ug | $314 | |
| A72-30G-50 | 50 ug | $545 | |
| A72-30G-BULK | BULK | Contact Us |
Overview:
AXIN2 plays an important role in the regulation of the stability of beta-catenin in the Wnt signaling pathway and Axin2-expressing cells themselves produce Wnt signals as well as long-range secreted Wnt inhibitors, suggesting an autocrine mechanism of stem cell self-renewal (1). AXIN2 is highly expressed in thymus, prostate, testis, ovary, and small intestine.The AXIN2 gene has been mapped to 17q23-q24, a region that shows frequent loss of heterozygosity in breast cancer, neuroblastoma, and other tumors. AXIN2 as a gene that is responsible for hereditary colorectal cancer and tooth agenesis that may be an indicator of cancer susceptibility (2).
Gene Aliases:
AXIL
Genbank Number:
References:
1. Lim, X.et.al: Interfollicular epidermal stem cells self-renew via autocrine Wnt signaling. Science 342: 1226-1230, 2013.
2. Lammi, L.et.al: Mutations in AXIN2 cause familial tooth agenesis and predispose to colorectal cancer. Am. J. Hum. Genet. 74: 1043-1050, 2004.
Purity:
Sample Purity Data. For specific information on a given lot, see related technical data sheet.
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Storage, Stability and Shipping:
Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Molecular Weight:
~130 kDa
There are no related publications available for this product.
Apoptosis/Autophagy, Cancer, Cell Cycle, JNK/SAPK Pathway, WNT Signaling
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