Overview:

TUBB1 or tubulin-beta 1 protein is a major constituent of microtubules. TUBB1 interaction with microtubule-associated proteins (MAPs) such as tau is fundamental for microtubule structure and function (1). Previous work suggested that the "microtubule binding domain" of tau (composed of three or four imperfect 18-amino acid repeats, separated by 13- or 14-amino acid inter-repeat regions) can bind to the C-terminal ends of both alpha and beta tubulin monomers. Studies revealed that TUBB1 is the target of various antitubulin agents used in the treatment of cancer. Subsequent studies have also concluded that TUBB1 mutations in clinical samples are rare, and unlikely to contribute to drug resistance (2).

References:

1. Chau, M.F. et al: The microtubule-associated protein tau cross-links to two distinct sites on each alpha and beta tubulin monomer via separate domains.". Biochemistry, 1999; 37 (51): 17692-703.

2. Berrieman, H.K. et al: Do beta-tubulin mutations have a role in resistance to chemotherapy?"Lancet Oncol, 2004; 5 (3): 158-64.