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EIF2AK4 (GCN2), Active

Recombinant human EIF2AK4 (192-1024) was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.
Catalog No. E12-11G


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Catalog No. Pack Size Price (USD)
E12-11G-05 5 ug $226
E12-11G-10 10 ug $325
E12-11G-BULK BULK Contact Us  


Overview:

EIF2AK4 or eukaryotic translation initiation factor 2 alpha kinase 4 belongs to a family of kinases that phosphorylate the alpha subunit of eukaryotic translation initiation factor-2 to downregulate protein synthesis in response to varied cellular stresses (1). The EIF2AK4 eIF2-alpha kinase regulates fatty-acid homeostasis in the liver during deprivation of an essential amino acid (2).


Gene Aliases:

GCN2; KIAA1338


Genbank Number:


References:


1. Berlanga, J. J. et.al: Characterization of a mammalian homolog of the GCN2 eukaryotic initiation factor 2-alpha kinase. Europ. J. Biochem. 265: 754-762, 1999.

2. Guo, F. et.al: The GCN2 eIF2-alpha kinase regulates fatty-acid homeostasis in the liver during deprivation of an essential amino acid. Cell Metab. 5: 103-114, 2007.


Specific Activity:

Sample Kinase Activity Plot. For specific information on a given lot, see related technical data sheet.


Purity:

Sample Purity Data. For specific information on a given lot, see related technical data sheet.


Storage, Stability and Shipping:

Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.


Molecular Weight:

~132 kDa



RESEARCH AREAS

Angiogenesis, Cellular Stress, Inflammation, Neurobiology, Ser/Thr Kinases


RELATED PRODUCTS


  EIF2AK2, Active, P80-11G

  RS Repeat Peptide, R55-58

  EIF2S1 Protein, E23-54H

  Modified EIF2S Peptide, E23-58B


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