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Recombinant human PTPN12 (1-355) was expressed in E. coli cells using a N-terminal GST tag.
Catalog No. P39-21G
Catalog No. | Pack Size | Price (USD) | |
---|---|---|---|
P39-21G-05 | 5 ug | $160 | |
P39-21G-10 | 10 ug | $226 | |
P39-21G-BULK | BULK | Contact Us |
Overview:
Protein tyrosine phosphatase-PEST (PTPN12), a ubiquitously expressed cytoplasmic tyrosine phosphatase, is thought to play an important role in cell adhesion and motility, cell migration, and signal transduction for antigen receptors in B and T lymphocytes (1). Signal transduction via tyrosine phosphorylation, normally fine-tuned by the concerted action of both protein tyrosine kinases and protein tyrosine phosphatases (PTPs), is a key mechanism in tumorigenesis. Studies suggest potential role for PTP-PEST in regulation of p130(cas) in mitogen- and cell adhesion-induced signaling events (2).
Gene Aliases:
PTP-PEST, PTPG1, tcag7.1075
Genbank Number:
References:
1. Angers-Loustau, A. et al: Protein tyrosine phosphatase-PEST regulates focal adhesion disassembly, migration, and cytokinesis in fibroblasts. J. Cell Biol. 1999; 144: 1019-31.
2. Garton, A.J. et al: Identification of p130(cas) as a substrate for the cytosolic protein tyrosine phosphatase PTP-PEST. Mol. Cell Biol. 1996; 16(11):6408-18.
Specific Activity:
Sample Enzyme Activity Plot. For specific information on a given lot, see related technical data sheet.
Purity:
Sample Purity Data. For specific information on a given lot, see related technical data sheet.
Storage, Stability and Shipping:
Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Molecular Weight:
~66kDa
Cancer, Inflammation, Invasion/Metastasis, JAK/STAT Pathway, Metabolic Disorder, Phosphatases, WNT Signaling
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