Overview:

SETMAR or SET domain and mariner transposase fusion gene is a nonhomologous end-joining repair protein that regulates genomic integration of exogenous DNA by opening chromatin and facilitating joining of DNA ends (1). SETMAR has histone methyltransferase activity and methylates 'Lys-4' and 'Lys-36' of histone H3. SETMAR also has DNA nicking activity and may play a role in DNA repair (2). Human Pso4 forms a stable complex with SETMAR that regulates Metnase function in DNA repair. SETMAR has sequence-specific DNA-binding activity and recognizes the 19-mer core of the 5'-terminal inverted repeats (TIRs) of the Hsmar1 element.

Gene Aliases:

METNASE

Genbank Number:

BC011635

References:

1. Lee, S.-H.et.al: The SET domain protein Metnase mediates foreign DNA integration and links integration to nonhomologous end-joining repair. Proc. Nat. Acad. Sci. 102: 18075-18080, 2005.

2. Liu, D.et.al: The human SETMAR protein preserves most of the activities of the ancestral Hsmar1 transposase. Molec. Cell. Biol. 27: 1125-1132, 2007.