Overview:

SENP8 (Sentrin-specific protease 8) is a cysteine protease belonging to the sentrin-specific protease family and catalyzes two crucial functions in the NEDD8 pathway. It was found that SENP8 is not a SUMO protease but functions on a small ubiquitin-related protein called NEDD8 (1). SENP8 is involved in the processing of full-length NEDD8 to its mature form and NEDD8 deconjugation from targeted proteins such as cullins or p53 (2).

Gene Aliases:

DEN1, NEDP1, PRSC2

Genbank Number:

NM_145204

References:

1. Mikolajczyk, J. et al: Small Ubiquitin-related Modifier (SUMO)-specific Proteases: PROFILING THE SPECIFICITIES AND ACTIVITIES OF HUMAN SENPs. The Journal of Biological Chemistry 282: 26217-26224, 2007.

2. Mendoza, H.M. et al: NEDP1, a highly conserved cysteine protease that deNEDDylates Cullins. J Biol Chem. 278(28):25637-43, 2003.