Mitogen-activated protein kinase 7 (MKK7 or MEK7) is a dual-specificity protein kinase of the STE7 family. Directly phosphorylates the Thr-Pro-Tyr motif located in the activation loop of JNK1/2 and activate the kinases in response to environmental stress, pro-inflammatory cytokines or developmental cues. The activation of MKK7 is mediated by various MAPKKKs, including mixed lineage protein kinases (MLKs) and MAPK/ERK kinase (MEK) kinase (MEKK1).
MAP2K7; MKK7; JNKK2; MAPKK7; PRKMK7; SKK4
1. Davis RJ. Signal transduction by the JNK group of MAP kinases. Cell. 103(2):239-52, 2000.
2. Chang L, et al: Mammalian MAP kinase signalling cascades. Nature. 410(6824):37-40, 2001.
3. Asaoka Y, et al: Diverse physiological functions of MKK4 and MKK7 during early embryogenesis. J Biochem. 48(4):393-401, 2010.
Sample Kinase Activity Plot. For specific information on a given lot, see related technical data sheet.
Sample Purity Data. For specific information on a given lot, see related technical data sheet.
Storage, Stability, and Shipping:
Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Angiogenesis, Apoptosis/Autophagy, Cancer, Cardiovascular Disease, ERK/MAPK Pathway, Invasion/Metastasis, Neurobiology, Ser/Thr Kinases