Rabbit Polyclonal Antibody
Catalog No. R29-63BR
Catalog No. | Pack Size | Price (USD) | |
---|---|---|---|
R29-63BR-100 | 100 ug | $270 | |
R29-63BR-BULK | BULK | Contact Us |
Overview:
Transcription factors of the nuclear factor κB (NF-κB)/Rel family play a pivotal role in inflammatory and immune responses in unstimulated cells, NF-κB is sequestered in the cytoplasm by its inhibitory proteins, the IκBs (1). NF-κB-activating agents can induce the phosphorylation of IκB’s, targeting them for rapid degradation through an ubiquitin-proteasome pathway, releasing NF-κB to enter the nucleus, where it regulates gene expression.
References:
1. Baeuerle, P. et al: Function and activation of NF-kappa B in the immune system. Annu Rev Immunol. 1994; 12: 141-79.
Specificity:
Recognizes the REL A (NFKB/p65) protein
Cross Reactivity:
Western blot human and mouse REL A
REL A from other species may also be detectable.
Host :
Rabbit
Immunogen:
Synthetic peptide corresponding to amino acids 527-531 of human REL A
Purification:
Affinity chromatography
Stability:
Store at 4oC (add 0.1% NaN3) for several months, and at -20oC for longer periods. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For optimal performance, avoid repeated handling and multiple freeze/thaw cycles.
Sample Data:
Representative Western blot with Anti-REL A (1:1000) using 20 ng human recombinant Rel A.
Sample Data:
Representative Western blot with Anti-REL A (1:1000) using 3 μg, 10 μg, and 30 μg of 3T6 cell lysate.
There are no related publications available for this product.
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