Overview:

UCHL5 (Ubiquitin carboxyl-terminal hydrolase isozyme L5) is a member of the peptidase C12 family of deubiquitinating enzymes and specially cleaves 'Lys-48'-linked polyubiquitin chains. UCHL5 is associated with the 19S regulatory subunit of the 26S proteasome and may play a role as a putative regulatory component of the INO80 complex (1). High expression of UCHL5 has also been indicated to be correlated with increased disease-specific survival in lymph-node-positive rectal cancer, suggesting that it could be a possible novel prognostic marker (2).

Gene Aliases:

UCH-L5, UCH37, CGI-70, INO80R

Genbank Number:

NM_001199261

References:

1. Yao, T.T. et al: Distinct modes of regulation of the Uch37 deubiquitinating enzyme in the proteasome and in the Ino80 chromatin-remodeling complex. Molecular cell 31(6): 909-17, 2008.

2. Arpalahti, L. et al: UCHL5 expression associates with improved survival in lymph-node-positive rectal cancer. Tumor Biology: 1-8, 2017.