Overview:

OTULIN (OTU deubiquitinase with linear linkage specificity) belongs to the family of peptidase C65 family of ubiquitin isopeptidases via removing ubiquitin from proteins (1). OTULIN specifically targets on Met1-linked polyubiquitin chains to repress the linear ubiquitin chain assembly complex (LUBAC) mediated ubiqitination (2). OTULIN deficiency leads to a TNF-related systemic inflammation and aotuimmunity in humans and mice model, and the neutralizing antibody can rescue the phenotypes (3).

Gene Aliases:

GUM; AIPDS; FAM105B

Genbank Number:

NM_138348

References:

1. Mevissen TE, et al. OTU deubiquitinases reveal mechanisms of linkage specificity and enable ubiquitin chain restriction analysis. Cell. 2013 Jul 3;154(1):169-84.

2. Keusekotten K, et al. OTULIN antagonizes LUBAC signaling by specifically hydrolyzing Met1-linked polyubiquitin. Cell. 2013 Jun 6;153(6):1312-26.

3. Damgaard RB, et al. The Deubiquitinase OTULIN Is an Essential Negative Regulator of Inflammation and Autoimmunity. Cell. 2016 Aug 25;166(5):1215-1230.