Overview:

Interferon-stimulated gene 15 (ISG15) encodes a ubiquitin-like protein that covalently conjugates to viral or cellular proteins to regulate the stability and function via the activation on the treatment of interferons (1). ISG15 conjugation to UBCH6 represses the activity to conjugate to ubiquitin, suggesting a link between ISG15 and ubiquitin systems (2). ISG15 is involved in the regulation of type I interferon-induced JNK signaling pathway by ISGylation of filamin B (3).

Gene Aliases:

G1P2; IP17; UCRP; IFI15; IMD38; hUCRP

Genbank Number:

NM_005101

References:

1. Zhao C, et al. Human ISG15 conjugation targets both IFN-induced and constitutively expressed proteins functioning in diverse cellular pathways. Proc Natl Acad Sci U S A. 2005 Jul 19;102(29):10200-5.

2. Takeuchi T, et al. Link between the ubiquitin conjugation system and the ISG15 conjugation system: ISG15 conjugation to the UbcH6 ubiquitin E2 enzyme. J Biochem. 2005 Dec;138(6):711-9.

3. Jeon YJ, et al. ISG15 modification of filamin B negatively regulates the type I interferon-induced JNK signalling pathway. EMBO Rep. 2009 Apr;10(4):374-80.