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AMSH, Active

Recombinant full-length human AMSH was expressed by baculovirus in Sf9 insect cells using an N-terminal His tag.
Catalog No. A565-380H


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Catalog No. Pack Size Price (USD)
A565-380H-05 5 ug $226
A565-380H-10 10 ug $325
A565-380H-BULK BULK Contact Us  


Overview:

AMSH (STAM binding protein) is a member of the JAMM metallo-enzyme family of deubiquitinating enzymes and is a ubiquitin isopeptidase found in the endosomes. It is involved in EGFR downregulation and regulates sorting of cell-surface receptors to the lysosome. The enzyme binds to the SH3 domain of STAM, which is required for MYC and cell growth (1). It has been hypothesized that mutations in AMSH are associated with Microcephaly-capillary malformation (2).


Gene Aliases:

STAMBP, MICCAP


Genbank Number:


References:


1. McCullough, John et al: AMSH is an endosome-associated ubiquitin isopeptidase. Journal of cell biology. vol. 166,4 (2004): 487-92.

2. McDonell, Laura M et al: Mutations in STAMBP, encoding a deubiquitinating enzyme, cause microcephaly-capillary malformation syndrome. Nature genetics 45(5): 556-62, 2013.


Specific Activity:

Sample Activity Plot. For specific information on a given lot, see related technical data sheet.


Purity:

Sample Purity Data. For specific information on a given lot, see related technical data sheet.


Storage, Stability, and Shipping:

Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.


Molecular Weight:

54 kDa



Product Datasheets



Safety Datasheet



There are no related publications available for this product.


RESEARCH AREAS

Cancer, Cardiovascular Disease, Cell Cycle, Cellular Stress, Invasion/Metastasis, Metabolic Disorder


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SIGNALCHEM BIOTECH INC.


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