Overview:

BAP1 (BRCA1 associated protein-1) is a deubiquitinating enzyme belonging to the ubiquitin C-terminal hydrolase subfamily and is involved in the ubiquitin removal from proteins. It binds to the RING finger domain of the BCRA1 and acts as a tumor suppressor (1). BAP1 mutations have been found to cause multiple tumour types and high tumour phenotype penetrance, suggesting that it may have a major role in inducing cancer growth (2).

Gene Aliases:

HUCEP-13, KIAA0272, Hucep-6, UCHL2

Genbank Number:

NM_004656

References:

1. Carbone, Michele et al: BAP1 and cancer. Nature reviews. Cancer vol. 13,3: 153-9, 2013

2. Jensen, D.E. et al: BAP1: a novel ubiquitin hydrolase which binds to the BRCA1 RING finger and enhances BRCA1-mediated cell growth suppression. Oncogene. 16,9: 1097–112, 1998.