Overview:

MINDY1, as a member of the motif interacting with Ub-containing novel DUB family, is widely expressed in human tissues and during development (1). It cleaves long polyUb chains through trimming chains from the distal end, suggesting a regulatory role in proteostasis (1). It has been reported that MINDY1 is associated with renal function, Chronic Kidney Disease (2), and Alzheimer’s disease (3) through several genome wide studies.

Gene Aliases:

FAM63A, MINDY lysine 48 deubiquitinase 1, MINDY-1

Genbank Number:

NM_018379

References:

1. Abdul Rehman SA, et al. MINDY-1 Is a Member of an Evolutionarily Conserved and Structurally Distinct New Family of Deubiquitinating Enzymes. Mol Cell, 2016 Jul 7;63(1):146-55.

2. Köttgen A, et al. New loci associated with kidney function and chronic kidney disease. Nat Genet, 2010 May;42(5):376-84.

3. Figgins JA, et al. Association studies of 22 candidate SNPs with late-onset Alzheimer's disease. Am J Med Genet B Neuropsychiatr Genet. 2009 Jun 5;150B(4):520-6.