Overview:

TNFAIP3 (Tumor necrosis factor alpha-induced protein 3) is a ubiquitin-editing enzyme that contains both ubiquitin ligase and deubiquitinase activities. The enzyme plays a role in immune and inflammatory responses of cytokines such as TNF-alpha and IL-1 beta, or pathogens via Toll-like receptors (TLRs) through inhibiting NFkB activity (1). TNFAIP3 has been found to be associated with rheumatoid arthritis (2).

Gene Aliases:

AISBL, A20, OTUD7C

Genbank Number:

NM_006290

References:

1. Heyninck, K et al: The zinc finger protein A20 inhibits TNF-induced NF-kappaB-dependent gene expression by interfering with an RIP- or TRAF2-mediated transactivation signal and directly binds to a novel NF-kappaB-inhibiting protein ABIN. Journal of cell biology vol. 145,7: 1471-82, 1999.

2. Stahl, E. A. et al: Genome-wide association study meta-analysis identifies seven new rheumatoid arthritis risk loci. Nature genetics 42,6: 508-14, 2010