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USP2, Active

Recombinant human USP2 (259-end), was expressed in E. coli cells using an N-terminal His tag.
Catalog No. U502-381H


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Catalog No. Pack Size Price (USD)
U502-381H-05 5 ug $226
U502-381H-10 10 ug $325
U502-381H-BULK BULK Contact Us  


Overview:

USP2 (Ubiquitin carboxyl-terminal hydrolase 2) is a member of the peptidase C19 superfamily and is a ubiquitin-specific protease that is essential for TNF-alpha (tumor necrosis factor alpha) -induced NF-kB (nuclear factor kB) signaling. The enzyme deubiquitinates polyubiquitinated target proteins like fatty acid synthase, murine double minute 2 (MDM2), MDM4/MDMX and cyclin D1. USP2 plays a role in G1/S cell-cycle progression in normal and cancer cells as it is a specific deubiquitinase for cyclin D1 (1). It is also involved in the regulation of the p53 pathway by targeting Mdm2, which is critical for maintaining genome integrity (2).


Gene Aliases:

UBP41


Genbank Number:


References:


1. Shan, J. et al: Suppression of cancer cell growth by promoting cyclin D1 degradation. Mol. Cell 36:469-476, 2009.

2. Stevenson, L. F. et al: The deubiquitinating enzyme USP2a regulates the p53 pathway by targeting Mdm2. EMBO journal 26(4): 976-986, 2007


Specific Activity:

Sample Activity Plot. For specific information on a given lot, see related technical data sheet.


Purity:

Sample Purity Data. For specific information on a given lot, see related technical data sheet.


Storage, Stability, and Shipping:

Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.


Molecular Weight:

40 kDa



Product Datasheets



Safety Datasheet



There are no related publications available for this product.


RESEARCH AREAS

Cancer, Cardiovascular Disease, Cell Cycle, Cellular Stress, Invasion/Metastasis, Metabolic Disorder


RELATED PRODUCTS


  DUB Reaction Buffer (4X), D01-09

  DUB Substrate I, U06-57


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