USP2 (Ubiquitin carboxyl-terminal hydrolase 2) is a member of the peptidase C19 superfamily and is a ubiquitin-specific protease that is essential for TNF-alpha (tumor necrosis factor alpha) -induced NF-kB (nuclear factor kB) signaling. The enzyme deubiquitinates polyubiquitinated target proteins like fatty acid synthase, murine double minute 2 (MDM2), MDM4/MDMX and cyclin D1. USP2 plays a role in G1/S cell-cycle progression in normal and cancer cells as it is a specific deubiquitinase for cyclin D1 (1). It is also involved in the regulation of the p53 pathway by targeting Mdm2, which is critical for maintaining genome integrity (2).
1. Shan, J. et al: Suppression of cancer cell growth by promoting cyclin D1 degradation. Mol. Cell 36:469-476, 2009.
2. Stevenson, L. F. et al: The deubiquitinating enzyme USP2a regulates the p53 pathway by targeting Mdm2. EMBO journal 26(4): 976-986, 2007
Sample Activity Plot. For specific information on a given lot, see related technical data sheet.
Sample Purity Data. For specific information on a given lot, see related technical data sheet.
Storage, Stability, and Shipping:
Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
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Cancer, Cardiovascular Disease, Cell Cycle, Cellular Stress, Invasion/Metastasis, Metabolic Disorder