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USP11, Active

Recombinant full-length human USP11 was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.
Catalog No. U511-380G


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Catalog No. Pack Size Price (USD)
U511-380G-05 5 ug $226
U511-380G-10 10 ug $325
U511-380G-BULK BULK Contact Us  


Overview:

USP11 (ubiquitin carboxyl-terminal hydrolase 11) is a member of the ubiquitin specific proteases family (USPs) and is a protease that functions in the removal of conjugated ubiquitin from target proteins and polyubiquitin chains. The enzyme cleaves preferentially 'Lys-6' and 'Lys-63'-linked ubiquitin chains and is involved in regulating pathways that lead to NF-kappa-B activation by regulating IκB kinase α (1). USP11 also binds to p21, a cyclin-dependent kinase inhibitor and plays an important role in regulating cell-cycle progression and DNA damage responses.


Gene Aliases:

UHX1


Genbank Number:


References:


1. Yamaguchi, T. et al. The deubiquitinating enzyme USP11 controls an IkappaB kinase alpha (IKKalpha)-p53 signaling pathway in response to tumor necrosis factor alpha (TNFalpha). J Biol Chem. 282(47):33943-8, 2007.

2. Tanggang, D. et al: Deubiquitylation and stabilization of p21 by USP11 is critical for cell-cycle progression and DNA damage responses. Proceedings of the National Academy of Sciences 115(18): 4678-4683, 2018.


Specific Activity:

Sample Activity Plot. For specific information on a given lot, see related technical data sheet.


Purity:

Sample Purity Data. For specific information on a given lot, see related technical data sheet.


Storage, Stability, and Shipping:

Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.


Molecular Weight:

136 kDa



Product Datasheets



Safety Datasheet



There are no related publications available for this product.


RESEARCH AREAS

Cancer, Cardiovascular Disease, Cell Cycle, Cellular Stress, Invasion/Metastasis, Metabolic Disorder


RELATED PRODUCTS


  DUB Reaction Buffer (4X), D01-09

  DUB Substrate I, U06-57


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