Overview:

USP15 (ubiquitin carboxyl-terminal hydrolase 15) is a member of the ubiquitin specific protease (USP) family of cysteine protease deubiquitination enzymes and regulates TGFB receptor signaling, NF-kappa-B and RNF41/NRDP1-PRKN pathways. The enzyme interacts with OP9 signalosome and is a key regulator of TGFB receptor signaling through deubiquitination of receptor-activated SMAD transcription factors (1). USP15 also plays a role in the regulation and stabilization of Human Papillomavirus (HPV) type 16 E6 protein, suggesting that E6 may be a target for USP15 DUB activity (2).

Gene Aliases:

KIAA0529, UNPH-2

Genbank Number:

NM_001252078

References:

1. Inui, M. et al: USP15 is a deubiquitylating enzyme for receptor-activated SMADs. Nat Cell Biol. 13(11):1368-75, 2011

2. Vos, Robin M et al: The ubiquitin-specific peptidase USP15 regulates human papillomavirus type 16 E6 protein stability. Journal of virology 83(17): 8885-92, 2009.