Overview:

USP16 (ubiquitin carboxyl-terminal hydrolase 16) is a deubiquitinating enzyme belonging to the ubiquitin-specific protease (USP) family and is involved in transcriptional regulation that controls cell differentiation, cell cycle and apoptosis through modulations with p16 Ink4a and p19 Arf. Downregulation of USP16 by truncated HBx may contribute to the growth of hepatocellular carcinoma cells (1). USP16 may also play a crucial role in provoking the self-renewal and/or senescence pathways in Down syndrome through the removal of ubiquitin from H2AK119, a critical mark for the maintenance of several somatic tissues (2).

Gene Aliases:

UBP-M

Genbank Number:

NM_006447

References:

1. Qian, Y. et al: USP16 Downregulation by Carboxyl-terminal Truncated HBx Promotes the Growth of Hepatocellular Carcinoma Cells. Scientific Reports 6, 33039, 2016.

2. Adorno, M. et al: Usp16 contributes to somatic stem-cell defects in Down's syndrome. Nature vol. 501(7467): 380-4, 2013.