Recombinant human CYLD (1-956) was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.
Catalog No. C578-380G
Catalog No. | Pack Size | Price (USD) | |
---|---|---|---|
C578-380G-05 | 5 ug | $226 | |
C578-380G-10 | 10 ug | $325 | |
C578-380G-BULK | BULK | Contact Us |
Overview:
CYLD is a cytoplasmic deubiquitinating enzyme, which removes ubiquitin molecules from various signaling proteins, and regulates the activities of many cellular and signaling processes. It plays a role in the regulation of inflammation, immunity, cell cycle progression, spermatogenesis, osteoclastogenesis, ciliogenesis, migration and tumorigenesis. (1) Several signaling pathways, such as the Nuclear Factor-kB (NF-kB), Wnt/β-catenin and c-Jun N-terminal kinase (JNK) pathways, and potentially others have been linked with or regulated by CYLD. (2) Mutations in CYLD gene have been associated with cylindromatosis, multiple familial trichoepithelioma, and Brooke-Spiegler syndrome. (3)
Gene Aliases:
EAC; MFT; SBS; TEM; BRSS; CDMT; MFT1; CYLD1; CYLDI; USPL2
Genbank Number:
References:
1. Bignell G.R. et al. Identification of the familial cylindromatosis tumour-suppressor gene. Nat Genet. 25(2):160–165, 2000.
2. Verhoeft, K.R. et al The cylindromatosis (CYLD) gene and head and neck tumorigenesis. Cancers Head Neck. 1: 10, 2016.
3. EntreZ Gene: CYLD cylindromatosis (turban tumor syndrome)
Specific Activity:
Sample Activity Plot. For specific information on a given lot, see related technical data sheet.
Purity:
Sample Purity Data. For specific information on a given lot, see related technical data sheet.
Storage, Stability, and Shipping:
Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Molecular Weight:
135 kDa
There are no related publications available for this product.
Cancer, Cell Cycle, Cellular Stress, Inflammation, JNK/SAPK Pathway, WNT Signaling
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