Rabbit Polyclonal Antibody
Catalog No. M15-63R
Catalog No. | Pack Size | Price (USD) | |
---|---|---|---|
M15-63R-100 | 100 ug | $595 | |
M15-63R-BULK | BULK | Contact Us |
Overview:
TAK1 is a serine/threonine protein kinase that mediates signaling by TGFbeta and morphogenetic protein (BMP) (1). In response to IL-1, TAK1 forms a kinase complex with TAB1 and this complex is required for the activation of nuclear factor kappa B (NfkB). TAK1 can also activate MAPK8/JNK and MAP2K4/MKK4 and thus play a role in the cell response to environmental stress. Tak1 is essential for thymocyte development and activation and deletion of TAK1 prevents maturation of single-positive thymocytes displaying CD4 or CD8 (2). Thymocytes lacking TAK1 fail to activate NfkB and JNK and are prone to apoptosis upon stimulation.
References:
1. Yamaguchi, K. et al: Identification of a member of the MAPKKK family as a potential mediator of TGF-beta signal transduction. Science 270: 2008-2011, 1995.
2. Liu, H.-H. et al: Essential role of TAK1 in thymocyte development and activation. Proc. Nat. Acad. Sci. 103: 11677-11682, 2006.
Specificity:
Recognizes the TAK1 protein
Cross Reactivity:
Human, Mouse and Rat
Host / Isotype / Clone#:
Rabbit, IgG
Immunogen:
TAK1 antibody was raised against a synthetic peptide corresponding to 14 amino acids near the amino-terminus of human TAK1 isoform a
Purification:
Affinity chromatography
Stability:
Store at 4oC (add 0.1% NaN3) for several months, and at -20oC for longer periods. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Sample Data:
Western blot analysis of TAK1 in Rat thymus cell lysate with TAK1 antibody at (A) 1, (B) 2, and (C) 4 ug/ml.
There are no related publications available for this product.
AKT/PKB Pathway, Angiogenesis, Cancer, Cell Cycle, Cellular Stress, ERK/MAPK Pathway, Inflammation, JAK/STAT Pathway, JNK/SAPK Pathway, NfkB Pathway, Ser/Thr Kinases, WNT Signaling
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