Overview:

MO25α (mouse protein 25 alpha) is a 40-kDa protein that interacts with the STE20-related adaptor-alpha (STRADα) pseudo kinase to form a regulatory complex capable of stimulating the activity of the LKB1 tumor suppressor protein kinase (1). LKB1 plays a critical role in cell proliferation, polarity and energy metabolism. LKB1 is mutated in the inherited Peutz-Jeghers cancer syndrome (PJS). MO25α binds directly to a conserved Trp-Glu-Phe sequence at the STRADαC terminus, and markedly enhances the binding of STRADα to LKB1 thereby increasing LKB1 catalytic activity (2).

Gene Aliases:

CAB39, CGI-66, FLJ22682

Genbank Number:

NM_016289

References:

1. Boudeau, J. et al: Analysis of the LKB1-STRAD-MO25 complex. J Cell Sci. 2004;117(Pt 26):6365-75.

2. Milburn, C.C. et al: Crystal structure of MO25 alpha in complex with the C terminus of the pseudo kinase STE20-related adaptor. Nat. Struct. Mol. Biol. 2004;11(2):193-200.