Recombinant full-length human EZH1 was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.
Catalog No. E395-30G
| Catalog No. | Pack Size | Price (USD) | |
|---|---|---|---|
| E395-30G-20 | 20 ug | $314 | |
| E395-30G-50 | 50 ug | $545 | |
| E395-30G-BULK | BULK | Contact Us |
Overview:
EZH1 (enhancer of zeste homolog 1) belongs to the polycomb group (PcG) protein and acts as the catalytic subunit of the PRC2/EED-EZH1 complex, which methylates 'Lys-27' of histone H3, leading to transcriptional repression of target genes. EZH1 is ubiquitously expressed. Compared to PRC2-EZH2, PRC2-EZH1 exhibits low levels of histone methyltransferase (HKMT) activity. Required for embryonic stem cell derivation and self-renewal, suggesting that it is involved in safeguarding embryonic stem cell identity.
Gene Aliases:
KIAA0388
Genbank Number:
References:
1. Margueron R, et al: Ezh1 and Ezh2 maintain repressive chromatin through different mechanisms. Mol Cell. 32(4):503-18, 2008.
2. Shen X, et al: EZH1 mediates methylation on histone H3 lysine 27 and complements EZH2 in maintaining stem cell identity and executing pluripotency. Mol Cell. 32(4):491-502, 2008.
Purity:
Sample Purity Data. For specific information on a given lot, see related technical data sheet.
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Storage, Stability, and Shipping:
Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Molecular Weight:
~130 kDa
There are no related publications available for this product.
Cancer, Inflammation, Neurobiology
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