SIRT1 Inhibitor
Catalog No. S35-904G
| Catalog No. | Pack Size | Price (USD) | |
|---|---|---|---|
| S35-904G-5 | 5 mg | $85 | |
| S35-904G-25 | 25 mg | $330 | |
| S35-904G-BULK | BULK | Contact Us |
Overview:
Initially shown to inhibit Sir2p (the yeast Sirt1 homolog) and create a conditional phenocopy of a sir2 deletion mutant in S. cerevisiae1. Cells grown in the presence of the drug have silencing defects at telomeres, silent mating-type loci and the ribosomal DNA1. Inhibits all class III HDACs (sirtuins) and alleviates gene silencing in Fragile X mental retardation syndrome2. Reverses ischemic preconditioning-induced cardioprotection in a mouse model3.
References:
1. A Bedalov et al. Proc. Natl. Acad. Sci. USA 2001 98:15113
2. R Biacsi et al. PLoS Genet. 2008 4(3):e1000017
3. SM Nadtochiy et al. Cardiovasc. Res. 2011 89:643
CAS Registry Number:
5690-03-09
Molecular Formula:
C13H10O2
Appearance:
White powder
Molecular Weight:
198.2
Purity:
>98% (TLC)
Solubilization:
May be dissolved in DMSO (>25 mg/ml) or ethanol (>25 mg/ml)
Aliases:
1,2-Dihydro-3H-naphtho[2,1-b]pyran-3-one
Storage and Stability:
Store desiccated as supplied at ambient temperature for up to 2 years. Store solutions at -20oC for up to 1 month.
Molecular Structure:
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There are no related publications available for this product.
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