Recombinant full-length human Troponin1 protein was expressed in E. coli cells using an N-terminal His tag.
Catalog No. T68-30H
| Catalog No. | Pack Size | Price (USD) | |
|---|---|---|---|
| T68-30H-20 | 20 ug | $215 | |
| T68-30H-50 | 50 ug | $435 | |
| T68-30H-BULK | BULK | Contact Us |
Overview:
Troponin1 is a member of the tropomyosin family and regulates the calcium sensitivity of the myofibril contractile apparatus of striated muscles. Troponin1 is part of a complex with troponin T and troponin C in which Troponin1 acts as an inhibitory subunit that blocks actin-myosin interactions and thereby mediates striated muscle relaxation (1). Troponin1 is expressed in cardiac and skeletal muscle during early development but is restricted to slow-twitch skeletal muscle fibers in adults. The Troponin1 protein prevents muscle contraction by inhibiting calcium-mediated conformational changes in actin-myosin complexes (2).
Gene Aliases:
TNNI1; DKFZp451O223; SSTNI; TNN1
Genbank Number:
References:
1. Tiso, N. et al: Fine mapping of five human skeletal muscle genes: alpha-tropomyosin, beta-tropomyosin, troponin-I slow-twitch, troponin-I fast-twitch, and troponin-C fast. Biochem. Biophys. Res. Commun. 230: 347-350, 1997.
2. Nadal-Ginard.et al: Molecular basis of cardiac performance: plasticity of the myocardium generated through protein isoform switches. J. Clin. Invest. 84: 1693-1700,198
Purity:
Sample Purity Data. For specific information on a given lot, see related technical data sheet.
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Storage, Stability and Shipping:
Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Molecular Weight:
~24 kDa
There are no related publications available for this product.
Cardiovascular Disease
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