Recombinant human INCENP (783-end) was expressed by baculovirus in Sf9 insect cells using an N-terminal His tag. This product can be used for Aurora B and Aurora C activation in vitro.
Catalog No. I30-31H
| Catalog No. | Pack Size | Price (USD) | |
|---|---|---|---|
| I30-31H-20 | 20 ug | $215 | |
| I30-31H-50 | 50 ug | $435 | |
| I30-31H-BULK | BULK | Contact Us |
Overview:
INCENP or inner centromere protein antigens 135/155kDa is a constitutively binding centromere proteins and 'passenger,' or transiently interacting, proteins. The overexpression of a truncation mutant of chicken INCENP and a chimeric CENPB:INCENP protein in mammalian cell culture disrupted both prometaphase chromosome alignment and completion of cytokinesis (1). INCENP forms a complex with the evolutionarily conserved family of Aurora B kinases which helps coordinate chromosome segregation, spindle behavior, and cytokinesis during mitosis (2).
Gene Aliases:
FLJ31633, MGC111393
Genbank Number:
References:
1. Mackay, A. M. et.al: A dominant mutant of inner centromere protein (INCENP), a chromosomal protein, disrupts prometaphase congression and cytokinesis. J. Cell Biol. 140: 991-1002, 1998.
2. Pereira, G. et.al: Separase regulates INCENP-Aurora B anaphase spindle function through Cdc14. Science 302: 2120-2124, 2003.
Purity:
Sample Purity Data. For specific information on a given lot, see related technical data sheet.
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Storage, Stability and Shipping:
Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Molecular Weight:
~19 kDa
There are no related publications available for this product.
Cell Cycle, Invasion/Metastasis
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