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PAK1, Unactive

Recombinant full-length human PAK1 was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag. Cannot be activated by CDC42.
Catalog No. P02-14G

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Catalog No. Pack Size Price (USD)
P02-14G-20 20 ug $215
P02-14G-50 50 ug $435
P02-14G-BULK BULK Contact Us  


PAK1 is a member of the p21-activated kinases (PAKs) which have been implicated in the regulation of cell morphology, motility and transformation. These serine/threonine kinases are activated by and are effectors of small GTPases, cdc 42 and Rac. PAK1 belongs to the Group I PAKs which also includes PAK2 and PAK3 (1). Pak1 is a key regulator of the actin cytoskeleton, adhesion and cell motility. Inactive dimeric Pak1 is mainly cytosolic and interaction with the activators Cdc42-GTP and Rac1-GTP stimulates the kinase at the sites of cellular protrusions forming adhesions to the extracellular matrix (2).

Gene Aliases:

PAKalpha, MGC130000, MGC130001

Genbank Number:


1. Jaffer, Z M. et al: p21-activated kinases: three more join the Pak. Int J Biochem Cell Biol. 2002 Jul;34(7):713-7.

2. Parrini, M C. et al: Spatiotemporal regulation of the Pak1 kinase. Biochem Soc Trans. 2005 Aug;33(Pt 4):646-8.


Sample Purity Data. For specific information on a given lot, see related technical data sheet.

Storage, Stability and Shipping:

Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.

Molecular Weight:

~88 kDa

Product Datasheets


Cancer, ERK/MAPK Pathway, Inflammation, Invasion/Metastasis, Neurobiology, Ser/Thr Kinases


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