PAK1 is a member of the p21-activated kinases (PAKs) which have been implicated in the regulation of cell morphology, motility and transformation. These serine/threonine kinases are activated by and are effectors of small GTPases, cdc 42 and Rac. PAK1 belongs to the Group I PAKs which also includes PAK2 and PAK3 (1). Pak1 is a key regulator of the actin cytoskeleton, adhesion and cell motility. Inactive dimeric Pak1 is mainly cytosolic and interaction with the activators Cdc42-GTP and Rac1-GTP stimulates the kinase at the sites of cellular protrusions forming adhesions to the extracellular matrix (2).
PAKalpha, MGC130000, MGC130001
1. Jaffer, Z M. et al: p21-activated kinases: three more join the Pak. Int J Biochem Cell Biol. 2002 Jul;34(7):713-7.
2. Parrini, M C. et al: Spatiotemporal regulation of the Pak1 kinase. Biochem Soc Trans. 2005 Aug;33(Pt 4):646-8.
Sample Purity Data. For specific information on a given lot, see related technical data sheet.
Storage, Stability and Shipping:
Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
BCQ Nguyen et al., Frondoside A from sea cucumber and nymphaeols from Okinawa propolis: Natural anti-cancer agents that selectively inhibit PAK1 in vitro Drug Discovery and therapeutics May 2017 10.5582/ddt.2017.01011
Berger A et al., PAK-dependent STAT5 serine phosphorylation is required for BCR-ABL-induced leukemogenesis Leukemia March 2014 10.1038/leu.2013.351
Kassardjian Ari et al., The Transcription Factor YY1 Is a Novel Substrate for Aurora B Kinase at G2/M Transition of the Cell Cycle PLoS One November 2012 10.1371/journal.pone.0050645
Regina Maisha et al., Use of Bionanotechnology to decipher the patterns of assemblage and interactions of multi-protein complexes not in journal August 2009
Cancer, ERK/MAPK Pathway, Inflammation, Invasion/Metastasis, Neurobiology, Ser/Thr Kinases