Overview:

RGS1 is a member of the regulator of G-protein signalling family and attenuates the signalling activity of G-proteins. RGS1 binds to activated GTP-bound G alpha subunit and acts as a GTPase activating protein (GAP) thereby increasing the rate of conversion of GTP to GDP and terminating the signal (1). RGS1 is extensively up-regulated in renal cell carcinoma (RCC) tissues and melanoma. In melanoma, RGS1 expression is significantly correlated with increased tumor thickness, mitotic rate and presence of vascular involvement. Furthermore, there is significant association between increasing RGS1 expression and reduced relapse-free survival as well as disease-specific survival (DSS) survival (2).

Gene Aliases:

IR20, IER1, 1R20, BL34

Genbank Number:

BC015510

References:

1. Sierra D A, et al: Evolution of the regulators of G-protein signaling multigene family in mouse and human. Genomics 79: 177-185, 2002.

2. Rangel J, et al: Novel role for RGS1 in melanoma progression. Am J Surg Pathol. 2008 Aug;32(8):1207-12