Home   >    Enzymes   >   Phosphodiesterases

PDE3B, Active

Recombinant human PDE3B (654-end) was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.
Catalog No. P91-31BG


Shop Online



Catalog No. Pack Size Price (USD)
P91-31BG-05 5 ug $259
P91-31BG-10 10 ug $380
P91-31BG-BULK BULK Contact Us  


Overview:

PDE3B is a member of the phosphodiesterase family of proteins that play a critical role in regulating intracellular levels of cAMP and cGMP. PDE3B has high affinity for cAMP and is inhibited by cGMP as well as specific inhibitors such as cilostamide and milrinone. PDE3B is phosphorylated and activated in response to insulin and agents that increase cAMP. Leptin can increase the activity of PDE3B in the hypothalamus leading to a decrease in cAMP concentration (1). PDE3B-knockout mice exhibited multiple alterations in regulation of lipolysis, lipogenesis, and insulin secretion, as well as signs of peripheral insulin resistance (2).


Gene Aliases:

HcGIP1; cGIPDE1


Genbank Number:


References:


1. Zhao A Z, et al: A phosphatidylinositol 3-kinase-phosphodiesterase 3B-cyclic AMP pathway in hypothalamic action of leptin on feeding. Nature Neurosci. 5: 727-728, 2002.

2. Choi Y H, et al: Alterations in regulation of energy homeostasis in cyclic nucleotide phosphodiesterase 3B-null mice. J. Clin. Invest. 116: 3240-3251, 2006.


Specific Activity:

Sample Phosphodiesterase Activity Plot. For specific information on a given lot, see related technical data sheet.


Purity:

Sample Purity Data. For specific information on a given lot, see related technical data sheet.


Storage, Stability and Shipping:

Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.


Molecular Weight:

~85 kDa



Product Datasheets



Safety Datasheet



RESEARCH AREAS

Cardiovascular Disease, Inflammation, Phosphodiesterases


RELATED PRODUCTS


  PDE2A, Active, P90-30G

  PDE4D, Active, P92-31DG

  PDE4A, Active, P92-31G

  PDE3A, Active, P91-31G


SIGNALCHEM BIOTECH INC.


About

Terms of Service

Privacy Policy

Get the latest resources, updates and offers in your inbox