Overview:

PDE1B is a member of the PDE protein superfamily that catalyzes the hydrolysis of the cyclic nucleotides cAMP and cGMP to the corresponding nucleoside 5-prime-monophosphates. PDE1B is a calmodulin-dependent enzyme that is stimulated by calcium-calmodulin complex (1). PDE1B is express in the lymphoblastic and leukemic cell lines and causes the cells to undergo apoptosis, suggesting PDE1B could be a novel therapeutic strategy for the treatment of leukemia (2). GM-CSF is a major regulator of monocyte to macrophage differentiation and this cytokine has been shown to up-regulate PDE1B.

Gene Aliases:

PDE1B1; PDES1B

Genbank Number:

NM_000924

References:

1. Yu, J.et.al: Identification and characterisation of a human calmodulin-stimulated phosphodiesterase PDE1B1. Cell. Signal. 9: 519-529, 1997.

2. Jiang, X. et.al: Inhibition of calmodulin-dependent phosphodiesterase induces apoptosis in human leukemic cells. Proc. Nat. Acad. Sci. 93: 11236-11241, 1996.