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PDE10A, Active

Recombinant human PDE10A (71-end) was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.
Catalog No. P98-31G


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Catalog No. Pack Size Price (USD)
P98-31G-05 5 ug $259
P98-31G-10 10 ug $380
P98-31G-BULK BULK Contact Us  


Overview:

PDE10A is a member of the phosphodiesterase family of proteins that play a critical role in regulating intracellular levels of cAMP and cGMP (1). PDE10A eliminates cAMP- and cGMP-mediated intracellular signaling by hydrolyzing the cyclic nucleotide to the corresponding nucleoside 5-prime monophosphate. PDE10A hydrolyzes cAMP and cGMP in transfected COS-7 cells (2). PDE10A has a 11-fold higher affinity for cGMP than cAMP and cAMP can efficiently inhibit cGMP phosphodiesterase activity of PDE10A. PDE10A is being used as a biomarker in clinical trials of gene-disease association and gene-environment interaction.


Gene Aliases:

HSPDE10A; FLJ11894; FLJ25677


Genbank Number:


References:


1. Fujishige, K. et.al: Cloning and characterization of a novel human phosphodiesterase that hydrolyzes both cAMP and cGMP (PDE10A). J. Biol. Chem. 274: 18438-18445, 1999.

2. Loughney, K et.al: Isolation and characterization of PDE10A, a novel human 3-prime, 5-prime-cyclic nucleotide phosphodiesterase. Gene 234: 109-117, 1999.


Specific Activity:

Sample Phosphodiesterase Activity Plot. For specific information on a given lot, see related technical data sheet.


Purity:

Sample Purity Data. For specific information on a given lot, see related technical data sheet.


Storage, Stability and Shipping:

Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.


Molecular Weight:

~102 kDa



Product Datasheets



Safety Datasheet



RESEARCH AREAS

Cardiovascular Disease, Inflammation, Phosphodiesterases


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