Overview:

PDE8B or phosphodiesterase 8B is a cyclic nucleotide phosphodiesterase (PDE) that catalyzes the hydrolysis of the second messenger cAMP (1). The recombinant PDE8B exhibits cAMP-PDE activity that is resistant to several PDE inhibitors. The cAMP hydrolytic activity of PDE8B is unaffected by cGMP and it does not display any cGMP mediated hydrolysis. Defects in PDE8B are a cause of autosomal dominant striatal degeneration (ADSD) (2). PDE8B plays a prominent role in degrading cAMP expression in human embryonic kidney cells.

Genbank Number:

NM_003719

References:

1. Hayashi, M. et.al: Genomic organization, chromosomal localization, and alternative splicing of the human phosphodiesterase 8B gene. Biochem. Biophys. Res. Commun. 297: 1253-1258, 2002.
2. Horvath, A. et.al: A cAMP-specific phosphodiesterase (PDE8B) that is mutated in adrenal hyperplasia is expressed widely in human and mouse tissues: a novel PDE8B isoform in human adrenal cortex. Europ. J. Hum. Genet. 16: 1245-1253, 2008.