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MEKK6 (ASK2), Active

Recombinant full-length human MEKK6 (ASK2) was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.
Catalog No. M14-10G


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Catalog No. Pack Size Price (USD)
M14-10G-05 5 ug $435
M14-10G-10 10 ug $655
M14-10G-BULK BULK Contact Us  


Overview:

MEKK6, or MAP3K6 (mitogen-activated protein kinase kinase kinase 6) or ASK2 is a member of the serine/threonine protein kinase family. MEKK6 (ASK2) was identified by its interaction with MAP3K5/ASK, a protein kinase and an activator of c-Jun kinase (MAPK7/JNK) and MAPK14/p38 kinase (1). MEKK6 cascades relay signals from the cell surface to the nucleus which result in gene transcription (2). MEKK6 activates the JNK and p38 pathway and induces apoptosis when overexpressed in stably transfected cells. MEKK6 transcript is expressed in several tissues, with the highest expression in heart and skeletal muscle.


Gene Aliases:

MAP3K6, MAPKKK6, MEKK6


Genbank Number:


References:


1. Wang, X. S. et al: MAPKKK6, a novel mitogen-activated protein kinase kinase kinase, that associates with MAPKKK5. Biochem. Biophys. Res. Commun. 253: 33-37, 1998.

2. Takeda, K. et al: Apoptosis signal-regulating kinase (ASK) 2 functions as a mitogen-activated protein kinase kinase kinase in a heteromeric complex with ASK1. J Biol Chem. 2007 Mar 9;282(10):7522-31.


Specific Activity:

Sample Activity Plot. For specific information on a given lot, see related technical data sheet.


Purity:

Sample Purity Data. For specific information on a given lot, see related technical data sheet.


Storage, Stability, and Shipping:

Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.


Molecular Weight:

180 kDa



Product Datasheets



There are no related publications available for this product.


RESEARCH AREAS

Apoptosis/Autophagy, Cancer, Cellular Stress, JNK/SAPK Pathway, p38 Pathway, Ser/Thr Kinases


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