Home   >    Proteins   >   Protein Kinases

PLK4, Active

Recombinant human PLK4 (1-836) was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.
Catalog No. P44-11G


Shop Online



Catalog No. Pack Size Price (USD)
P44-11G-05 5 ug $226
P44-11G-10 10 ug $325
P44-11G-BULK BULK Contact Us  


Overview:

PLK4 or polo-like kinase 4 is a member of the polo family of serine/threonine protein kinases which localizes to centrioles, complex microtubule-based structures found in centrosomes, and regulates centriole duplication during the cell cycle. The overexpression of PLK4 triggered the simultaneous formation of multiple procentrioles around each preexisting centriole which resulting in centriole amplification and thus, Plk4-induced centriole biogenesis in human cells (1).The reduced Plk4 gene dosage increases the probability of mitotic errors and cancer development (2).


Gene Aliases:

SAK, STK18


Genbank Number:


References:


1. Kleylein-Sohn, J. et.al: Plk4-induced centriole biogenesis in human cells. Dev. Cell 13: 190-202, 2007.

2. Ko, M. A. et.al: Plk4 haploinsufficiency causes mitotic infidelity and carcinogenesis. Nature Genet. 37: 883-888, 2005.


Specific Activity:

Sample Kinase Activity Plot. For specific information on a given lot, see related technical data sheet.


Purity:

Sample Purity Data. For specific information on a given lot, see related technical data sheet.


Storage, Stability and Shipping:

Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.


Molecular Weight:

~140 kDa



There are no related publications available for this product.


RESEARCH AREAS

Cancer, Cell Cycle, Ser/Thr Kinases


RELATED PRODUCTS


  PLK1, Active, P41-10H

  PLK2, Active, P42-10G

  PLK3, Active, P43-13G

  PLKtide, P41-58


SIGNALCHEM BIOTECH INC.


About

Terms of Service

Privacy Policy

Get the latest resources, updates and offers in your inbox