PLK4 or polo-like kinase 4 is a member of the polo family of serine/threonine protein kinases which localizes to centrioles, complex microtubule-based structures found in centrosomes, and regulates centriole duplication during the cell cycle. The overexpression of PLK4 triggered the simultaneous formation of multiple procentrioles around each preexisting centriole which resulting in centriole amplification and thus, Plk4-induced centriole biogenesis in human cells (1).The reduced Plk4 gene dosage increases the probability of mitotic errors and cancer development (2).
1. Kleylein-Sohn, J. et.al: Plk4-induced centriole biogenesis in human cells. Dev. Cell 13: 190-202, 2007.
2. Ko, M. A. et.al: Plk4 haploinsufficiency causes mitotic infidelity and carcinogenesis. Nature Genet. 37: 883-888, 2005.
Sample Kinase Activity Plot. For specific information on a given lot, see related technical data sheet.
Sample Purity Data. For specific information on a given lot, see related technical data sheet.
Storage, Stability and Shipping:
Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
There are no related publications available for this product.
Cancer, Cell Cycle, Ser/Thr Kinases