Home   >    Proteins   >   Protein Kinases

GLK, Active

Recombinant human GLK (1-380) was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.
Catalog No. M25-11G


Shop Online



Catalog No. Pack Size Price (USD)
M25-11G-05 5 ug $435
M25-11G-10 10 ug $655
M25-11G-BULK BULK Contact Us  


Overview:

GLK is a member of the STE20 family of serine/threonine protein kinases and contains N-terminal catalytic domain and C-terminal regulatory domain. GLK is upstream of the MEKK1 target and is stimulated by UV radiation and TNF- and can lead to the activation of the JNK signaling pathway. GLK can directly activate PKC-θ during TCR signaling and people with systemic lupus erythematosus show considerable enhanced GLK expression and activation of PKC-θ and the kinase IKK in T cells (1). GLK can act as a pro-apoptotic kinase which orchestrates activation of BAX via the concerted posttranscriptional modulation of PUMA, BAD, and BIM (2).


Gene Aliases:

MAP4K3; MAPKKKK3; MEKKK3; RAB8IPL1


Genbank Number:


References:


1. Chuang, H C. et al: The kinase GLK controls autoimmunity and NF-κB signaling by activating the kinase PKC-θ in T cells. Nat Immunol. 2011 Oct 9;12(11):1113-8.

2. Lam, D. et al: MAP4K3 modulates cell death via the post-transcriptional regulation of BH3-only proteins. Proc Natl Acad Sci U S A. 2009 Jul 21;106(29):11978-83.


Specific Activity:

Sample Kinase Activity Plot. For specific information on a given lot, see related technical data sheet.


Purity:

Sample Purity Data. For specific information on a given lot, see related technical data sheet.


Storage, Stability and Shipping:

Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.


Molecular Weight:

~70 kDa



There are no related publications available for this product.


RESEARCH AREAS

JNK/SAPK Pathway, Metabolic Disorder, Ser/Thr Kinases


RELATED PRODUCTS


  Kinase Dilution Buffer III, K23-09

  Kinase Assay Buffer I, K01-09

  ATP Stock Solution, A50-09

  PKA Substrate, C01-58


SIGNALCHEM BIOTECH INC.


About

Terms of Service

Privacy Policy

Get the latest resources, updates and offers in your inbox