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PKC theta, Active

Recombinant full-length human PKCtheta was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.
Catalog No. P74-10G

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Catalog No. Pack Size Price (USD)
P74-10G-05 5 ug $226
P74-10G-10 10 ug $325
P74-10G-BULK BULK Contact Us  


Protein Kinase C, theta (PKCθ) is important component in the intracellular signaling cascade (1). Recent studies have suggested that local accumulation of fat metabolites inside skeletal muscle may activate a serine kinase cascade involving PKC-theta leading to defects in insulin signaling and glucose transport in skeletal muscle (2). Insulin resistance plays a primary role in the development of type 2 diabetes and may be related to alterations in fat metabolism. PKC-theta is a crucial component mediating fat-induced insulin resistance in skeletal muscle and is a potential therapeutic target for the treatment of type 2 diabetes (2).

Gene Aliases:

PRKCQ, PRKCT, MGC126514, MGC141919, nPKC-theta

Genbank Number:


1. Manicassamy, S. and Sun, Z. The critical role of protein kinase C-theta in Fas/Fas ligand-mediated apoptosis. J. Immunol. 2007;178(1):312-9.

2. Kim, J K. et al: PKC-theta knockout mice are protected from fat-induced insulin resistance. J. Clin. Invest. 2004;114(6):823-7.

Specific Activity:

Sample Kinase Activity Plot. For specific information on a given lot, see related technical data sheet.


Sample Purity Data. For specific information on a given lot, see related technical data sheet.

Storage, Stability and Shipping:

Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.

Molecular Weight:

~110 kDa


Apoptosis/Autophagy, Cardiovascular Disease, ERK/MAPK Pathway, Neurobiology, NfkB Pathway, PKA/PKC Pathway, Ser/Thr Kinases


  PKC epsilon, Active, P65-10G

  Anti-PKC delta, P64-63R

  Anti-PKC theta, P74-63R

  Anti-PKC mu, P72-63R



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