Overview:

PRMT6 (protein arginine methyltransferase 6), an arginine methyltransferase that exhibits type I PRMT activity and catalyzes the formation of both omega-N monomethylarginine (MMA) and asymmetrical dimethylarginine (aDMA), with a strong preference for the formation of aDMA. It can methylate itself. PRMT6 does not recognize the same substrates as PRMT4/CARM1 and displays limited substrate overlap with PRMT1. It resides in the nucleus along with PRMT1, PRMT2, and PRMT4, whereas PRMT3 and PRMT5 GFP fusions localize exclusively to the cytoplasm.

Gene Aliases:

HRMT1L6

Genbank Number:

NM_018137

References:

1. Frankel A, et al: The novel human protein arginine N-methyltransferase PRMT6 is a nuclear enzyme displaying unique substrate specificity. J Biol Chem. 277(5):3537-43, 2002.

2. Miranda TB, et al: Protein arginine methyltransferase 6 specifically methylates the nonhistone chromatin protein HMGA1a. Biochem Biophys Res Commun. 336(3):831-5, 2005.