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SUV420H1 (KMT5B), Active

Recombinant full-length human SUV420H1 (KMT5B) was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.
Catalog No. S351-380G

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Catalog No. Pack Size Price (USD)
S351-380G-05 5 ug $259
S351-380G-10 10 ug $380
S351-380G-BULK BULK Contact Us  


Histone-lysine N-methyltransferase, Suppressor of variegation 4-20 homolog 1 SUV420H1 specifically trimethylates 'Lys-20' of histone H4, which in turn acts as a specific tag for epigenetic transcriptional repression. Located in pericentric heterochromatin regions, and plays a central role in the establishment of constitutive heterochromatin in these regions. Interacts with a family of proteins that display similarity with dual-specificity phosphatases (dsPTPases) mediated by its SET domains.

Gene Aliases:

KMT5B, CGI-85, MGC21161, MGC703

Genbank Number:


1. Tryndyak VP, et al: Loss of DNA methylation and histone H4 lysine 20 trimethylation in human breast cancer cells is associated with aberrant expression of DNA methyl-transferase 1, Suv4-20h2 histone methyltransferase and methyl-binding proteins. Cancer Biol Ther. 5(1):65-70, 2006.

2. Lai CH, et al: Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics. Genome Res. 10(5):703-13, 2000.

Specific Activity:

Sample Enzyme Activity Plot. For specific information on a given lot, see related technical data sheet.


Sample Purity Data. For specific information on a given lot, see related technical data sheet.

Storage, Stability, and Shipping:

Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.

Molecular Weight:

160 kDa

Product Datasheets

Safety Datasheet

There are no related publications available for this product.


Apoptosis/Autophagy, Cancer, Cell Cycle, Neurobiology



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