Overview:

Histone-lysine N-methyltransferase, Suppressor of variegation 4-20 homolog 1 SUV420H1 specifically trimethylates 'Lys-20' of histone H4, which in turn acts as a specific tag for epigenetic transcriptional repression. Located in pericentric heterochromatin regions, and plays a central role in the establishment of constitutive heterochromatin in these regions. Interacts with a family of proteins that display similarity with dual-specificity phosphatases (dsPTPases) mediated by its SET domains.

Gene Aliases:

KMT5B, CGI-85, MGC21161, MGC703

Genbank Number:

BC103498

References:

1. Tryndyak VP, et al: Loss of DNA methylation and histone H4 lysine 20 trimethylation in human breast cancer cells is associated with aberrant expression of DNA methyl-transferase 1, Suv4-20h2 histone methyltransferase and methyl-binding proteins. Cancer Biol Ther. 5(1):65-70, 2006.

2. Lai CH, et al: Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics. Genome Res. 10(5):703-13, 2000.