Recombinant human MLL2 (5317-end) was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.
Catalog No. M342-381G
| Catalog No. | Pack Size | Price (USD) | |
|---|---|---|---|
| M342-381G-05 | 5 ug | $259 | |
| M342-381G-10 | 10 ug | $380 | |
| M342-381G-BULK | BULK | Contact Us |
Overview:
Histone-lysine N-methyltransferase 2D, also known as mixed-lineage leukemia 2 (MLL2), methylates 'Lys-4' of histone H3 (H3K4me). Acts as a coactivator for estrogen receptor by being recruited by ESR1, thereby activating transcription. MLL2/KMT2D is among the most frequently mutated genes in a variety of pediatric tumors.
Gene Aliases:
MLL2; MLL4; KMT2D; AAD10; ALR; CAGL114; KABUK1; KMS; TNRC21
Genbank Number:
References:
1. Rao RC, et al: Hijacked in cancer: the KMT2 (MLL) family of methyltransferases. Nat Rev Cancer. 15(6):334-46. 2015.
2. Huether R. et al: The landscape of somatic mutations in epigenetic regulators across 1,000 paediatric cancer genomes. Nat Commun 5: 3630. 2014.
http://www.uniprot.org/uniprot/O14686
Specific Activity:
Sample Kinase Activity Plot. For specific information on a given lot, see related technical data sheet.
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Purity:
Sample Purity Data. For specific information on a given lot, see related technical data sheet.
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Storage, Stability, and Shipping:
Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Molecular Weight:
51 kDa
Cancer
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Karakkat JV et al., The metabolic sensor PASK is a histone 3 kinase that also regulates H3K4 methylation by associating with H3K4 MLL2 methyltransferase complex. Nucleic Acids Research September 2019 10.1093/nar/gkz786
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