TAOK1 is a serine/threonine-protein kinase involved in regulation of the p38-containing stress-responsive MAP kinase pathway and extracellular signal-regulated protein kinase (ERK) kinases (MEKs) (1). The activation of and binding to MEK3 by TAOK1 implicates TAOK1 in the regulation of the p38-containing stress-responsive MAP kinase pathway. A microtubule affinity-regulating kinase kinase, TAOK1 (also known as MARKK) is an important regulator of mitotic progression, required for both chromosome congression and checkpoint-induced anaphase delay (2).
PSK2, MARKK, MAP3K16, FLJ14314, KIAA1361
1. Hutchison, M. et al: Isolation of TAO1, a protein kinase that activates MEKs in stress-activated protein kinase cascades. J. Biol. Chem. 1998; 273(44):28625-32.
2. Draviam, V.M. et al: A functional genomic screen identifies a role for TAO1 kinase in spindle-checkpoint signalling. Nat. Cell Biol. 2007; 9(5):556-64.
Sample Kinase Activity Plot. For specific information on a given lot, see related technical data sheet.
Sample Purity Data. For specific information on a given lot, see related technical data sheet.
Storage, Stability and Shipping:
Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Garg R et al., Rnd3 interacts with TAO kinases and contributes to mitotic cell rounding and spindle positioning Journal of cell science February 2020 10.1242/jcs.235895
Morris J et al et al., Prostate-derived Sterile 20-like Kinases (PSKs/TAOKs) Phosphorylate Tau Protein and Are Activated in Tangle-bearing Neurons in Alzheimer Disease Journal of Biological Chemistry April 2013 10.1074/jbc.M112.448183
Morris J et al et al., A new TAO kinase inhibitor reduces tau phosphorylation at sites associated with neurodegeneration in human tauopathies Acta Neuropathologica Communications May 2018 10.1186/s40478-018-0539-8
Yeng Koo Chuay et al., Targeting TAO Kinases Using a New Inhibitor Compound Delays Mitosis and Induces Mitotic Cell Death in Centrosome Amplified Breast Cancer Cells Mol Cancer Thera August 2017 10.1158/1535-7163.MCT-17-0077
Cancer, Inflammation, Invasion/Metastasis, JNK/SAPK Pathway, p38 Pathway, Ser/Thr Kinases