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TAOK1, Active

Recombinant human TAOK1 (1-314) was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.
Catalog No. T24-11G


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Catalog No. Pack Size Price (USD)
T24-11G-05 5 ug $226
T24-11G-10 10 ug $325
T24-11G-BULK BULK Contact Us  


Overview:

TAOK1 is a serine/threonine-protein kinase involved in regulation of the p38-containing stress-responsive MAP kinase pathway and extracellular signal-regulated protein kinase (ERK) kinases (MEKs) (1). The activation of and binding to MEK3 by TAOK1 implicates TAOK1 in the regulation of the p38-containing stress-responsive MAP kinase pathway. A microtubule affinity-regulating kinase kinase, TAOK1 (also known as MARKK) is an important regulator of mitotic progression, required for both chromosome congression and checkpoint-induced anaphase delay (2).


Gene Aliases:

PSK2, MARKK, MAP3K16, FLJ14314, KIAA1361


Genbank Number:


References:


1. Hutchison, M. et al: Isolation of TAO1, a protein kinase that activates MEKs in stress-activated protein kinase cascades. J. Biol. Chem. 1998; 273(44):28625-32.

2. Draviam, V.M. et al: A functional genomic screen identifies a role for TAO1 kinase in spindle-checkpoint signalling. Nat. Cell Biol. 2007; 9(5):556-64.


Specific Activity:

Sample Kinase Activity Plot. For specific information on a given lot, see related technical data sheet.


Purity:

Sample Purity Data. For specific information on a given lot, see related technical data sheet.


Storage, Stability and Shipping:

Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.


Molecular Weight:

~63 kDa



Product Datasheets



RESEARCH AREAS

Cancer, Inflammation, Invasion/Metastasis, JNK/SAPK Pathway, p38 Pathway, Ser/Thr Kinases


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