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TAOK2, Active

Recombinant human TAOK2 (1-314) was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.
Catalog No. T25-11G


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Catalog No. Pack Size Price (USD)
T25-11G-05 5 ug $226
T25-11G-10 10 ug $325
T25-11G-BULK BULK Contact Us  


Overview:

Thousand and one-amino acid protein kinase 2 (TAOK 2) is part of the stress-sensitive kinase cascade and activation of and binding to MKK3 by TAOK2 implicates it in the regulation of the p38-containing stress-responsive MAP kinase pathway (1). TAOK2 protein kinase activates p38 mitogen-activated protein kinase cascade in vitro and in cells by phosphorylating the MAP/ERK kinases MKK3 and MKK6. TAO2 may play an important role in the activation of specific intracellular signaling pathways that are unique to osmotic stress (2).


Gene Aliases:

PSK, PSK1, TAO1, TAO2, MAP3K17, KIAA0881


Genbank Number:


References:


1. Hutchison, M. et al: Isolation of TAO1, a protein kinase that activates MEKs in stress-activated protein kinase cascades. J. Biol. Chem. 1998; 273:28625-32.

2. Chen, Z. et al: TAO (thousand-and-one amino acid) protein kinases mediate signaling from carbachol to p38 mitogen-activated protein kinase and ternary complex factors. J. Biol. Chem. 2003;278:22278-83.


Specific Activity:

Sample Kinase Activity Plot. For specific information on a given lot, see related technical data sheet.


Purity:

Sample Purity Data. For specific information on a given lot, see related technical data sheet.


Storage, Stability and Shipping:

Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.


Molecular Weight:

~63 kDa



RESEARCH AREAS

Cancer, Inflammation, Invasion/Metastasis, JNK/SAPK Pathway, p38 Pathway, Ser/Thr Kinases


RELATED PRODUCTS


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  CDK4/CyclinD3, Active, C31-18G


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