Thousand and one-amino acid protein kinase 2 (TAOK 2) is part of the stress-sensitive kinase cascade and activation of and binding to MKK3 by TAOK2 implicates it in the regulation of the p38-containing stress-responsive MAP kinase pathway (1). TAOK2 protein kinase activates p38 mitogen-activated protein kinase cascade in vitro and in cells by phosphorylating the MAP/ERK kinases MKK3 and MKK6. TAO2 may play an important role in the activation of specific intracellular signaling pathways that are unique to osmotic stress (2).
PSK, PSK1, TAO1, TAO2, MAP3K17, KIAA0881
1. Hutchison, M. et al: Isolation of TAO1, a protein kinase that activates MEKs in stress-activated protein kinase cascades. J. Biol. Chem. 1998; 273:28625-32.
2. Chen, Z. et al: TAO (thousand-and-one amino acid) protein kinases mediate signaling from carbachol to p38 mitogen-activated protein kinase and ternary complex factors. J. Biol. Chem. 2003;278:22278-83.
Sample Kinase Activity Plot. For specific information on a given lot, see related technical data sheet.
Sample Purity Data. For specific information on a given lot, see related technical data sheet.
Storage, Stability and Shipping:
Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Garg R et al., Rnd3 interacts with TAO kinases and contributes to mitotic cell rounding and spindle positioning Journal of cell science February 2020 10.1242/jcs.235895
Morris J et al et al., Prostate-derived Sterile 20-like Kinases (PSKs/TAOKs) Phosphorylate Tau Protein and Are Activated in Tangle-bearing Neurons in Alzheimer Disease Journal of Biological Chemistry April 2013 10.1074/jbc.M112.448183
Morris J et al et al., A new TAO kinase inhibitor reduces tau phosphorylation at sites associated with neurodegeneration in human tauopathies Acta Neuropathologica Communications May 2018 10.1186/s40478-018-0539-8
Yeng Koo Chuay et al., Targeting TAO Kinases Using a New Inhibitor Compound Delays Mitosis and Induces Mitotic Cell Death in Centrosome Amplified Breast Cancer Cells Mol Cancer Thera August 2017 10.1158/1535-7163.MCT-17-0077
Cancer, Inflammation, Invasion/Metastasis, JNK/SAPK Pathway, p38 Pathway, Ser/Thr Kinases