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CDC7 Protein

Recombinant full-length human CDC7 was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.
Catalog No. C26-30G


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Catalog No. Pack Size Price (USD)
C26-30G-20 20 ug $215
C26-30G-50 50 ug $435
C26-30G-BULK BULK Contact Us  


Overview:

CDC7 is a cell division cycle protein that is critical for the G1/S transition and initiation of DNA replication during the cell division cycle. Overexpression of CDC7 gene product may be associated with neoplastic transformation for some tumors. Inhibition of CDC7 in cancer cells impairs progression through S phase, inducing a p53-independent apoptotic cell death, whereas in normal cells, it does not affect cell viability (1). Inhibition of CDC7 kinase activity in cancer cells restricts DNA replication and induces apoptosis. CDC7 phosphorylates the minichromosome maintenance protein 2 (Mcm2), a component of the DNA replicative helicase needed for genome duplication (2).


Gene Aliases:

CDC7L1; HsCDC7; Hsk1; huCDC7; MGC117361; MGC126237; MGC126238


Genbank Number:


References:


1. Montagnoli, A. et al: Targeting cell division cycle 7 kinase: a new approach for cancer therapy. Clin Cancer Res. 2010 Sep 15;16(18):4503-8.

2. Chuang, L C. et al: Phosphorylation of Mcm2 by Cdc7 promotes pre-replication complex assembly during cell-cycle re-entry. Mol Cell. 2009 Jul 31;35(2):206-16.


Purity:

Sample Purity Data. For specific information on a given lot, see related technical data sheet.


Storage, Stability and Shipping:

Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.


Molecular Weight:

~94 kDa



Product Datasheets



There are no related publications available for this product.


RESEARCH AREAS

Cancer, Cell Cycle, Ser/Thr Kinases


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