ERK8 as a distinct member of the MAPK family that is activated by a Src-dependent signaling pathway, involved in control of its cellular localization by nuclear exclusion, and suggest a key role for this MAP kinase in the regulation of the biological activities of this nuclear receptor (1). ERK8 plays an important role in the response to, or repair of, DNA single strand breaks (2).
MAPK15, ERK7, ERK8
1. Rossi.M.et.al: Extracellular signal-regulated kinase 8 (ERK8) controls estrogen-related receptor α (ERRα) cellular localization and inhibits its transcriptional activity. J Biol Chem. 2011 Mar 11;286(10):8507-22.
2. Iva V. Klevernic. Et.al: Regulation of the activity and expression of ERK8 by DNA damage. Science direct. January 12, 2009.
Sample Kinase Activity Plot. For specific information on a given lot, see related technical data sheet.
Sample Purity Data. For specific information on a given lot, see related technical data sheet.
Storage, Stability, and Shipping:
Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Angiogenesis, Apoptosis/Autophagy, Cancer, Cardiovascular Disease, ERK/MAPK Pathway, Invasion/Metastasis, Neurobiology, Ser/Thr Kinases