Overview:

PDE9A is a member of the phosphodiesterase (PDE) family that catalyzes the hydrolysis of cGMP to the monophosphate and thus plays an important role in signal transduction by regulating the intracellular concentration of cyclic nucleotides (1). Multiple transcript variants encoding several different isoforms have been found for PDE9A (2). These mRNAs differ in the use of specific combinations of exons located at the 5' end of the gene while the 3' half, encoding the catalytic domain of the protein, always has the same combination of exons. PDE9A has been used in the study of gene- disease association, gene-environment interaction, and pharmacogenomic/toxicogenomic. PDE9A is mainly expressed in spleen, small intestine, and brain.

Gene Aliases:

FLJ90181; HSPDE9A2

Genbank Number:

NM_001001567

References:

1. Fisher, D A. et al: Isolation and characterization of PDE9A, a novel human cGMP-specific phosphodiesterase. J. Biol. Chem. 273: 15559-15564, 1998.

2. Soderling, S H. et al: Identification and characterization of a novel family of cyclic nucleotide phosphodiesterases. J. Biol. Chem. 273: 15553-15558, 1998.