Recombinant full-length human CyclinC was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.
Catalog No. C80-30G
| Catalog No. | Pack Size | Price (USD) | |
|---|---|---|---|
| C80-30G-20 | 20 ug | $215 | |
| C80-30G-50 | 50 ug | $435 | |
| C80-30G-BULK | BULK | Contact Us |
Overview:
Cyclin C is a member of the cyclin family of proteins and interacts with the cyclin-dependent kinase 8 (CDK8) and induces the phophorylation of the carboxy-terminal domain of the large subunit of RNA polymerase II. The mRNA levels of Cyclin C fluctuate during the cell cycle and peak at the G1 phase. Cyclin C acts as a critical regulator of the G0/G1 transition of human Hematopoietic stem cells (1). Cyclin C can also combine with CDK3 to stimulate Rb phosphorylation at S807/811 during the G0/G1 transition, and this phosphorylation is required for cells to exit G0 efficiently (2).
Gene Aliases:
CCNC, CycC
Genbank Number:
References:
1. Miyata, Y. et al: Cyclin C regulates human hematopoietic stem/progenitor cell quiescence. Stem Cells. 2010 Feb; 28(2): 308-17.
2. Ren, S. et al: Cyclin C/cdk3 promotes Rb-dependent G0 exit. Cell. 2004 Apr 16;117(2):239-51.
Purity:
Sample Purity Data. For specific information on a given lot, see related technical data sheet.
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Storage, Stability and Shipping:
Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Molecular Weight:
~55 kDa
There are no related publications available for this product.
Cancer, Cell Cycle
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CyclinD3 Protein, C81-30B3G
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